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In the fourth quarter of 2025, the Janus Henderson Mid Cap Growth Managed Account delivered a robust performance, significantly surpassing its benchmark. The portfolio achieved a gross return of 1.20%, while the Russell Midcap® Growth Index saw a decline of -3.70%. This outperformance highlights the effectiveness of the account's investment strategy during a dynamic market period.

Janus Henderson Mid Cap Growth Fund Excels Amidst Market Optimism

The stellar performance of the Janus Henderson Mid Cap Growth Managed Account in the final quarter of 2025 was largely attributable to astute stock selection, particularly within the industrials and healthcare sectors. These strategic picks proved to be significant contributors to the portfolio's positive relative returns, demonstrating the fund manager's expertise in identifying resilient and high-potential companies. However, holdings in the consumer discretionary and real estate sectors faced challenges, acting as detractors to overall performance.

During this period, broader market sentiment was buoyed by several factors. A series of encouraging corporate earnings reports provided a solid foundation for investor confidence. Concurrently, increasing anticipation of potential interest rate cuts by the Federal Reserve fueled optimism, suggesting a more favorable monetary policy environment ahead. Adding to this positive outlook, inflation figures remained relatively subdued, offering the Federal Reserve additional flexibility to potentially implement further rate reductions, thereby creating breathing room for economic expansion.

The account's success in navigating these market conditions underscores a disciplined investment approach that prioritizes companies with sustainable growth prospects and strong competitive advantages. This focus on fundamentals allows the portfolio to thrive even when certain sectors experience headwinds. Looking forward, the fund remains vigilant against potential market volatility and continues to adapt its strategy to emerging trends, such as advancements in artificial intelligence, while upholding strict criteria for investment selections to ensure long-term value creation.

The impressive results of the Janus Henderson Mid Cap Growth Managed Account in Q4 2025 serve as a compelling illustration of how active management and rigorous stock selection can yield substantial alpha, even in complex market environments. This performance offers valuable insights for investors seeking growth opportunities within the mid-cap segment, reinforcing the importance of fundamental analysis and a forward-looking perspective.